In addition to problems of safety, reprogramming thus far been a very inefficient process – only about one in every 1,000 mature cells is successfully reprogrammed.

In biology, reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development or in cell culture. [1] Such control is also often …

Although aging has long been considered an inevitable process, strategies to delay and potentially even reverse the aging process have recently been developed. Here, we review …

Aug 14, 2025 · Cell reprogramming is the process of reverting mature, specialised cells into induced pluripotent stem cells. Reprogramming also refers to the erasure and re …

Dec 13, 2024 · Cell reprogramming is the act of reverting mature, specialised cells into induced pluripotent stem cells, also known as iPS cells. This process requires a stem or progenitor cell …

Mar 27, 2025 · This review summarizes the recent advances in cell reprogramming mediated by transcription factors or chemical molecules, followed by elaborating on the important roles of …

In 2006, scientists led by Shinya Yamanaka at Kyoto University in Japan pioneered a new technology, known as induced pluripotent stem cells, or iPSC for short. This breakthrough …

Nov 12, 2014 · Here we present a comprehensive historical review of stem cells and cellular reprogramming, and illustrate the developing synergy between many previously unconnected …

Apr 23, 2025 · In this article, we examine the current understanding of the mechanisms underlying epigenetic reprogramming, how it may influence aging, and the extent to which it could enable …

Reprogramming is the result of large-scale changes in the epigenetic profile and gene-expression pattern of a cell, induced by the over-expression of key transcription factors, which regulate …