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RyR1-Mediated CICR Plays Minimal Role in Normal Skeletal Muscle Contraction
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.
18don MSN
Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
1 Department of Experimental Medical Science, Lund University, Lund, Sweden 2 Vascular Biology Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark The final, ...
A dataset named CARDIOPEG has been uploaded to the Dryad website. It contains all the individual experiments used for the figures in the article.
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