Instead, CICR acts as a dormant but dangerous silent risk factor, staying quiet under normal conditions yet becoming a major driver of pathology when RyR1 signaling is disrupted. This model resolves a ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

What Jimmy Kimmel said on his first night back after suspension over Charlie Kirk comments GE Appliances plant still feeling the effects after 150 immigrant workers had legal status revoked Trump ...

Phoenix Suns rookie 7-footer Khaman Maluach walked onto the portable spotlight stage during last week’s fan fest at PHX Arena to cheers and applause, but something looked different about him. His arms ...

The Aspen Institute has announced that Dan Porterfield will complete his service as president and CEO in the summer of 2026 after more than eight years at the helm. Since joining the institute in 2018 ...

The COVID-19 pandemic is inflicting high and rising human costs worldwide, and the necessary protection measures are severely impacting economic activity. As a result of the pandemic, the global ...

Cars clogged the exit from Heritage High School as the over-capacity stadium emptied. The Mountaineers had the football with a one-point lead, seemingly destined for victory over rival William Blount.

Lochie Sargeant is now back to his normal life after undergoing heart surgery in March for a condition he had no idea he even had until he passed out at work. The 22-year-old carpenter was a regular ...