A review in Clinical Epigenetics synthesizes growing evidence that paternal lifestyle and environmental exposures such as ...

Researchers at Karolinska Institutet have discovered how cells can adjust their gene activity to survive when oxygen runs low ...

New research in C. elegans from scientists at Howard Hughes Medical Institute (HHMI) helps explain how changes in the parents’ lysosomes that promote longevity are transferred to their offspring.

HHMI Janelia Research Campus Senior Group Leader Meng Wang and her team study longevity. They've shown that by overexpressing an enzyme in the lysosomes of the roundworm C. elegans, they can extend ...

Salt stress remains a critical challenge for plant growth, especially in crops like pea (Pisum sativum L.). This study explores the role of histone modifications in regulating pea's response to salt ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The flexibility of the spatio-temporal genome ...

(A) DNA methylation is maintained by DNMT1 on hemimethylated DNA after replication, while DNMT3A/3B catalyse de novo methylation on unmethylated DNA. In mammals, this modification is primarily found ...

Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Glioblastoma (GBM), a highly aggressive and malignant form of primary adult brain cancer ...

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

INTRODUCTION & BACKGROUND: Recent studies indicate that in the MDX mouse model of Duchenne muscle dystrophy (DMD) nitric oxide (NO) production is significantly compromised leading to skeletal muscle, ...