Receptor in cerebellum provides new insights into molecular basis of ataxia

Researchers at Ruhr University Bochum, Germany, identified a receptor that plays a crucial role in stress-induced motor ...
News-Medical.Net

Breakthrough in cancer therapy targets key protein interaction to suppress tumors

Researchers at the Francis Crick Institute and Vividion Therapeutics have identified chemical compounds that can precisely block the interaction between the major cancer-driving gene RAS, and a key ...
Medical Xpress

GLP-1 receptor agonists may protect the liver during alcohol consumption

Anti-obesity drugs such as semaglutide (Ozempic, Wegovy) are also promising for the treatment of alcohol use disorder and alcohol-associated liver disease, as growing evidence suggests they reduce the ...
C&EN

Pseudomonas aeruginosa Activates the NOD-like Receptor Signaling Pathway by Targeting Nasopharyngeal Cells throughout the Whole Respiratory Tract

Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and ...
Morningstar

Lilly's Mounjaro (tirzepatide), a GIP/GLP-1 dual receptor agonist, reduced A1C by an average of 2.2% in a Phase 3 trial of children and adolescents with type 2 diabetes

"Type 2 diabetes in children and teens is increasing at an alarming rate, yet treatment options are limited, and this patient population remains underserved," said Kenneth Custer, Ph.D., executive ...
Medscape

Oral GLP-1 Receptor Agonist Orforglipron Yields Dose-Dependent Weight Loss

VIENNA — Adults with obesity but without diabetes who took the investigational, oral GLP-1 receptor agonist orforglipron for 72 weeks lost significantly more weight than those on placebo, according to ...
C&EN

Strategic Design of Triple GLP-1R/GCGR/GIPR Agonists with Varied Receptor Potency: Achieving Comparable Glycemic and Weight Reduction Effects

Department of Pharmacy, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, P. R. China School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, P. R. China ...