The rapid identification of respiratory virus outbreaks is needed to enable rational and effective public health interventions. We developed new quantitative approaches for simultaneous ...

Facilities operated by the US Department of Energy (DOE) are required to have extensive worker safety and health programs by regulation. We describe how Argonne National Laboratory (ANL) has ...

Announcing ACS Nano Medicine We’re excited to announce our new journal— ACS Nano Medicine —a new addition to the family of ACS journals. “The broad scope of ACS Nano Medicine, encompassing fundamental ...

Transferrin receptor 1 (TfR1) is a ubiquitously expressed receptor characterized by rapid internalization kinetics and efficient receptor recycling, making it an attractive target for drug delivery.

Lysosome-targeting chimeras represent a promising strategy for degrading extracellular and membrane proteins via the lysosomal pathway, but the available receptor options remain limited. Herein, we ...

MDM2 is a key negative regulator of the tumor suppressor p53 and an attractive target for cancer therapy. We report the discovery of MD-4251, the first orally efficacious MDM2 degrader developed using ...

Current toxicant identification mainly relies on subjective and blind toxicity testing and compound screening. This could overlook the sensitive toxicity end point and key toxicants due to the random ...

The application of a flexible Zn–air battery (FZAB) in next-generation wearable electronics is mainly hindered by the sluggish oxygen reduction/evolution reaction (ORR/OER) and unstable Zn/electrolyte ...

Quantifying surface-specific kinetics of organic oxidation in heterogeneous catalytic systems remains a critical challenge due to the interplay of adsorption and complex reaction mechanisms. In this ...

Direct synthesis of acid–base-stable copper carboxylate metal–organic frameworks (MOFs) is of great significance but faces substantial challenges. Herein, a nanoenvelope strategy was proposed to ...

This study presents a novel approach utilizing matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) for rapid single-cell analysis, enabling multiomic data acquisition ...

Designing ideal materials with simultaneously high selectivity, high capacity, fast kinetics, and moderate regeneration for hydrocarbon separations remains challenging, restricting the advance of ...