It wasn't her unwanted fame or Ted's drinking or his other women that broke Joan Kennedy - it was Ted leaving Mary Jo Kopechne for dead at Chappaquiddick.

Chronic disappointment can train the brain to expect pain instead of reward. Restoring hope means reawakening dopamine through small actions, enriched environments, and new desire.

Researchers at Scripps identified a brain circuit in the paraventricular thalamus that links alcohol use to relief from withdrawal stress, explaining relapse and pointing to potential treatments for ...