Physician's Weekly

Tryptase Ratio Formula Improves ED Anaphylaxis Diagnosis

A ratio-based tryptase formula for diagnosing pediatric anaphylaxis in the ED demonstrated higher diagnostic performance than ...
ascopubs.org

Point-of-Care Urine Metabolomics Test to Diagnose Colorectal Cancers in Low- and Middle-Income Countries: A Pilot Controlled Trial in Southwestern Nigeria

This was a pilot-controlled trial carried out among 72 patients (34 cases and 38 controls) in southwestern Nigeria. The cases were those with histopathological diagnosis of CRC while controls were ...
ahajournals.org

Point-of-Care Placental Growth Factor for Predicting Adverse Outcomes in Sierra Leone

PlGF (placental growth factor) concentrations are lower in preeclampsia, a major cause of maternal death; testing improves diagnosis and outcomes. We evaluated 2 novel, whole blood, point-of-care PlGF ...
koaa

Science behind the spark: The difference between positive and negative lightning strikes

Some lightning strikes are much more rare and can pack more of a punch. This is due to the different type of charge of the strike. When thunderstorms form, raindrops and ice particles will rub against ...
Kotaku

Every Positive And Negative Scale-Bearing Merchant Deal In Nightreign

You can fight this mysterious merchant, or maybe it's better to take it up on an offer you can't refuse Elden Ring Windows Games In Elden Ring Nightreign, right before you fight the Nightlord Libra, ...
Medscape

Less Invasive Screening May Identify Barrett’s Esophagus Earlier

A new combination modality demonstrated excellent sensitivity and negative predictive value compared with endoscopy in a prospective study of at-risk veterans screened for Barrett’s esophagus (BE) and ...
ascopubs.org

Predictive value of PIK3CA mutations for response to CDK4/6 inhibitors in hormone receptor-positive, HER2-negative metastatic breast cancer: A systematic review and meta-analysis.

Trastuzumab deruxtecan (T-DXd) in HER2-positive advanced breast cancer (ABC) with active CNS metastases: Real world data. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...
BMJ

Prevalence of serious bacterial infections and performance of inflammatory markers in febrile infants with and without proven viral illness

1 Department of Paediatric Medicine, Kandang Kerbau Women's and Children’s Hospital, Singapore 2 Department of Children’s Emergency, Kandang Kerbau Women's and Children’s Hospital, Singapore 3 ...
lupus.bmj

Validation cohort of a tool to predict proliferative histological class in lupus nephritis based on clinical and laboratory data: LUCAS Study (Lupus Nephritis Class Assessment ...

Objectives Primary: To validate a previously developed lupus nephritis (LN) histologic class predictor tool (III or IV±(V) vs V). In this instrument, urinary sediment, anti-dsDNA antibody and serum ...
BMJ

Association between programmed electrical stimulation inducibility and arrhythmic risk in hypertrophic cardiomyopathy: a systematic review and meta-analysis

Background Risk stratification for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) remains challenging. Programmed electrical stimulation (PES) is not endorsed by current guidelines, ...
rheumatologyadvisor

The Challenges of Diagnosing Seronegative Rheumatic Diseases

Credit: Getty Images Dr Salahuddin Kazi, MD, comments on the challenges of diagnosing seronegative rheumatic diseases and discusses a case presentation that highlights these difficulties. The ability ...