Abstract: This study models the dynamics of ATP depletion and reactive oxygen species (ROS) accumulation in cardiac muscle cells under the influence of solar proton flux (SPF), focusing on both ...

Abstract: Global single-valued biomarkers, such as ejection fraction, are widely used in clinical practice to assess cardiac function. However, they only approximate the heart's true 3D deformation ...

China’s official gauge of manufacturing activity has stayed in contraction for a sixth consecutive month in September, providing more fuel for calls to step up government support amid persistent ...

Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL. (T.P., L.L., C.-K.S., M.W., H.-Y.L., Y.H., E.T ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Instead, CICR acts as a dormant but dangerous silent risk factor, staying quiet under normal conditions yet becoming a major driver of pathology when RyR1 signaling is disrupted. This model resolves a ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...