Scientists studying tiny roundworms have uncovered how the secrets of a long life can be passed from parents to their ...

HHMI Janelia Research Campus Senior Group Leader Meng Wang and her team study longevity. They've shown that by overexpressing ...

Salt stress remains a critical challenge for plant growth, especially in crops like pea (Pisum sativum L.). This study explores the role of histone modifications in regulating pea's response to salt ...

(A) DNA methylation is maintained by DNMT1 on hemimethylated DNA after replication, while DNMT3A/3B catalyse de novo methylation on unmethylated DNA. In mammals, this modification is primarily found ...

Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Glioblastoma (GBM), a highly aggressive and malignant form of primary adult brain cancer ...

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

Aging is the primary risk factor for numerous life-threatening diseases and has long been a central focus of biological research. Epigenetic reprogramming, a process that can modulate cell fate and ...

Epigenetics plays a critical role in human health by regulating gene expression without the direct modification of DNA sequence. Aberrant epigenetic modifications mediated by changes in DNA and ...

Cardiovascular disease often culminates in heart failure, a hallmark of which is fibrosis, a form of tissue scarring. Cardiac fibrosis initially repairs damaged heart tissue, but it can quickly become ...