Some bacterial-infecting viruses use ‘sponges’ to mop up defence molecules, but bacteria can fight back by responding when a sponge captures decoy molecules. Read the paper: A miniature CRISPR–Cas10 ...

MIT researchers have dramatically lowered the error rate of prime editing, a technique with promise for treating numerous genetic disorders. A genome editing method called prime editing could one day ...

Magnesium is essential to Cas9’s function, but many studies on the protein are done in a solution with a magnesium concentration of 10 mmol/L, higher than the approximately 1–2 mmol/L that is usually ...

Our friendly – and not so friendly – gut bacteria lie at the core of healthy ageing. Research is now revealing what it takes to maintain a youthful microbiome ...

Optimized approach for universal chromosomal DNA rearrangements achieves as high as 20% insertion efficiency, mobilizing genomic DNA at the megabase scale.

For decades, gene-editing science has been limited to making small, precise edits to human DNA, akin to correcting typos in the genetic code. Arc Institute researchers are changing that paradigm with ...

The researchers made one synthetic receptor for each candidate. When this synthetic receptor spotted a microbial molecule, it didn’t trigger a standard immune alarm. Instead, it flipped a ...