Nobel laureate Shimon Sakaguchi reflects on the role of regulatory T cells in peripheral immune tolerance and how the cells ...

Immune Cell Transporters as Mediators of Renal and Vascular Dysfunction and blood pressure Immune cells - including macrophages, ...

By examining genomic variation more closely, scientists can now identify new disease connections with greater speed and accuracy. For centuries, scientists have recognized that certain illnesses can ...

Scientists have developed a highly sensitive single-cell tool that can help uncover links to complex diseases. Known as ...

Regulatory T cells, which prevent the immune system from attacking the body, were the subject of this year’s Physiology or ...

The deadliest type of brain cancer does something doctors didn't expect: it thins the skull. New research shows glioblastoma goes beyond just attacking the brain; it also weakens the bone protecting ...

An overview of how genetics associated with schizophrenia and bipolar can influence how cells communicate, ultimately ...

During a live event, Ann F. Mohrbacher, MD, discussed outcomes from the latest follow-up of the ZUMA-7 and TRANSFORM trials.

DuoCAR20.19.22-D95 targets CD19, CD20, and CD22, addressing antigen escape in B-cell malignancies like B-ALL and B-NHL. Early-stage trials show no safety concerns for DuoCAR20.19.22-D95, with ongoing ...

Researchers at the University of Pittsburgh have discovered that the harsh environment inside tumors, characterized by low oxygen and high acidity, induces stress in T cells’ mitochondria, which then ...

Tumors are stressful places for cancer-fighting immune cells. Low oxygen, high acid levels, and other stressors put strain on mitochondria, the cell's energy factories, leading to T cell exhaustion ...

The CD20 inhibitor Ocrevus (ocrelizumab) rapidly depletes immune B-cells in people with multiple sclerosis (MS), as expected, but ongoing treatment also leads to changes in immune T-cells, a new study ...