The New England Journal of Medicine

Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer

In this phase 3, open-label, randomized trial, we enrolled patients with ER-positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer who had received one previous line ...
Frontiers

Role of mitochondrial quality control in neurodegenerative disease progression

Neurodegenerative diseases are a diverse group of neurological disorders, in which abnormal mitochondrial function is closely associated with their development and progression. This has generated ...
C&EN

Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria

Department of Chemistry, University of Cape Town, Rondebosch ,7701 Cape Town, South Africa Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925 Cape Town, ...
ahajournals.org

Endothelium- and Fibroblast-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Aortic Aneurysm

Thoracic (TAA) and abdominal (AAA) aortic aneurysm are life-threatening diseases characterized by dilation, inflammation, and structural weakness; development of pharmacological therapies is ...
Frontiers

SATB1 in cancer progression and metastasis: mechanisms and therapeutic potential

1 Department of Bioscience, Changchun Normal University, Changchun, China 2 Key Laboratory of Molecular Epigenetics of Ministry of Education, College of Life Sciences, Northeast Normal University, ...
C&EN

Development and Optimization of Piracetam and Shatavarin IV-Loaded Nanoemulsion for Alzheimer’s Disease Therapy: In Silico and Experimental Analysis

Department of Pharmacology. School of Pharmaceutical Education and Research. Jamia Hamdard, New Delhi 110062, India ...