Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have identified ...

The pentaspline pulsed field ablation catheter achieves pulmonary vein isolation using 8 stacked, pose-specific applications with rotation. The morphology of pose-specific, single or double ...

A primary goal of cardiologists is to identify and deliver targeted therapies to individuals at risk for myocardial infarction. Although the presence and severity of atherosclerosis is a commonly used ...

In 2012, the American Heart Association (AHA) published the first Scientific Statement addressing the evaluation and management of neurodevelopmental outcomes in children with congenital heart disease ...

In this article, the authors studied the role of Prdm16, an artery-specific transcription factor, in hindlimb flow recovery. To test the expression of Prdm16 under physiological and pathological ...

The study by Gopalasingam et al published in this issue of Circulation explored the effects of chronic oral KE supplementation on hemodynamic parameters and exercise performance in patients with type ...

Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardial ischemia/reperfusion injury. Tafazzin is an ...

Whether factor V Leiden is associated with lower bleeding risk in patients with acute coronary syndromes using (dual) antiplatelet therapy has yet to be investigated. To assess whether factor V Leiden ...

The transport of interstitial fluid and solutes into lymphatic vessels is important for maintaining interstitial homeostasis and delivering antigens and soluble factors to the lymph node for immune ...

Lymphatic vessels function to drain interstitial fluid from a variety of tissues. Although shear stress generated by fluid flow is known to trigger lymphatic expansion and remodeling, the molecular ...

Background— Heparin, used clinically as an anticoagulant, also has antiinflammatory properties and has been described to inhibit interferon (IFN)-γ responses in endothelial cells. We investigated the ...

While our understanding of the single-cell gene expression patterns underlying the transformation of vascular cell types during the progression of atherosclerosis is rapidly improving, the clinical ...