DNA transcription is a tightly choreographed event: How RNA polymerase II regulates the dance

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing ...
Nature

RNA Transcription by RNA Polymerase: Prokaryotes vs Eukaryotes

Gene expression is linked to RNA transcription, which cannot happen without RNA polymerase. However, this is where the similarities between prokaryote and eukaryote expression end. Central to the ...
BioTechniques

Switching gears: novel platform spills secrets of transcription’s speed regulation

The mammalian elongation complex has remained a mystery – until researchers discovered how it controls its speed.
ScienceAlert on MSN

New 'Mutation Hotspot' Discovered in The Human Genome

Scientists have pinpointed precise regions in the human genome where DNA is most likely to develop a mutation.
JSTOR Daily

RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 3 (January 18, 2022), pp. 1-7 (7 pages) Elongating RNA polymerase II (Pol II) can be paused or arrested ...
Medical Xpress

Unlocking key insights into gene expression using a novel mouse model

A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as reported by researchers from Science Tokyo. The team engineered mice to produce ...
WPRI 12

Codexis and Aldevron Enter Exclusive Licensing Agreement for Codex® HiCap RNA Polymerase

REDWOOD CITY, Calif. and FARGO, N.D., Dec. 13, 2023 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company, today announced it has entered into an agreement with ...