If you can't delete an ISO file as the file is open in your System, check if it is mounted as a drive or not. Uses these proven fixes to resolve the issue.

In this article, we explain the reasons why the AsIO3.sys file may not be accessible and how you can fix the issue. Can’t open AsIO3.sys!

Like the proverbial bad penny, the Diagnostic Tracking Service patch KB 3022345 appears to be corrupting Windows files — or at least, convincing Microsoft’s System File Checker SFC /scannow ...