Researchers have described a large set of previously unrecognized enzymatic domains—named the Lipocone superfamily—and outlined their evolutionary pathway from bacterial defense molecules to key ...

Protein Structure and Function Prediction Publication Trend The graph below shows the total number of publications each year in Protein Structure and Function Prediction.

Recent breakthroughs in artificial intelligence have transformed protein structure biology from a data-limited discipline into a data-driven frontier of ...

Researchers who developed protein folding software, and used it to predict new, useful proteins win the Nobel.

The protein "MIPS" changes its internal structure when it becomes active. Its disordered active center becomes a defined structure with special functions. The protein plays a key role in the ...

AlphaFold3 uses AI to helps scientists more accurately predict how proteins interact with other biological molecules.

Semirational protein design is a combination of rational and directed evolution methods. 9 Scientists consider this strategy more effective because they can use computational or bioinformatic modeling ...

The 2023 Lasker Award for Basic Medical Research underscores the value of an AI system that predicts the three-dimensional structure of proteins from the one-dimensional sequence of their amino acids.

For most proteins, structure is function. The complex three-dimensional shapes that proteins adopt create folds and pockets that can accomplish the remarkably improbable: driving chemical ...

Researchers knew that the ability to determine protein structure without relying on tedious experiments would unlock a plethora of applications—better drug targets, easy protein function determination ...

In the ERC project HelixMold, a team from TU Graz developed a method for the computer-based design of artificial proteins, with a focus on custom biocatalysts for pharmaceutical applications or ...