Matching One Column Data with Another in Excel. If you don't have a keen eye and a perfect memory, you probably can't spot all the differences between two data columns in a large worksheet.

How to compare columns in Microsoft Excel As stated, we can use the Excel VLOOKUP function to find and match different data or find differences in two columns.

If one of the rows in a one-column data set contains "cat" and the other contains "Cat" in the same column, Excel considers the values to be unique.

A row-by-row formatting rule is as easy to apply as a column-by-column in Microsoft Excel, but you might not get the results you thought you would.

If you need to conditionally split values into multiple columns in Microsoft Excel, consider using the IF() function. Here's how.