Before going over their fundamental differences, let's address the main question. Yes, Python can do virtually everything Excel can. But it’s not an apples-to-apples comparison.

For instance, PyXLL-Jupyter can integrate data from your Excel workbook into a Jupyter Notebook using a single command. This enables you to analyze massive datasets quickly.

Python integration in Excel won’t require additional software or add-ons and is instead part of Excel’s built-in connectors and Power Query.

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