Kaleido Scope

In Type 1 diabetes, verapamil prevents decline of IGF-1 and promotes beta-cell IGF-1 signaling

Now UAB researchers, led by Guanlan Xu, Ph.D., and Shalev drilled down further into the mechanism underlying verapamil’s beneficial effect. In a paper published in Diabetes, they show that, in Type 1 ...
Medscape

Customizing the Targeting of IGF-1 Receptor

The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal ...
Hosted on MSN

Too Much Protein Could Actually Shorten Your Lifespan, According to Longevity Experts

Experts reveal how your protein habits might impact your lifespan more than you think. Overconsumption of animal-based protein raises IGF-1 levels—a growth hormone linked to increased risk of chronic ...
Nature

Plasma androgens, IGF-1, body size, and prostate cancer risk: a synthetic review

We present a review of the epidemiological evidence for relations of prostate cancer risk to circulating total and bioavailable androgens, to alterations in the metabolism of insulin-like growth ...
Business Wire

Viridian Therapeutics Announces Positive Clinical Data in Healthy Volunteer Study and Selects VRDN-003 as Potential Best-in-Class Subcutaneous anti-IGF-1R Program with Extended ...

- VRDN-003 clinical data exceeded expectations with extended half-life of 40-50 days, 4-5x longer than VRDN-001, supporting a potential best-in-class, low-volume, less frequent, self-administered ...