G protein-coupled receptors (GPCRs) are essential for cell signal transduction and comprise the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple ...
This new technique for studying cell receptors could have sweeping implications for drug development
Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...
Dr. Anh Nguyen, co-lead author from MIPS with strong expertise in AI approaches to drug-receptor interactions, emphasized the importance of these interactions. "Interactions between molecules and ...
Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. An international team of ...
Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is ...
Researchers have uncovered how a protein called MRAP2 acts as a key regulator of hunger. It helps move the appetite receptor ...
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