Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

The Baker lab at the Institute for Protein Design at the University of Washington School of Medicine continues to drive innovation in AI-driven advances for protein design. This time, the team used ...

An MIT-developed AI model has designed dozens of lab-confirmed protein binders for targets long considered out of reach, offering a new tool for drug discovery and ...

For the field of drug development, hitting the right target with atomic precision to achieve therapeutic effect remains the core challenge. While traditional R&D pipelines are dependent on ...

A multicolored protein structure is blurred at the edges and comes into focus toward the center. Detail of a protein designed using a tool called ProteinMPNN Credit: Ian C. Haydon/UW Institute for ...

Designing drugs is a bit like playing with Polly Pocket. The vintage toy is a plastic clam shell that contains a multi-bedroom house, a skating rink, a disco dance floor, and other fun scenarios. Kids ...