The amino acid side chains of proteins undergo various post-translational modifications (PTMs) which significantly impact protein function and mediate complex cellular events. Measuring the dynamics, ...

At the University of Oxford, scientists have developed a nanopore technology that can identify three different post-translational modifications (PTMs) in individual proteins, even deep within long ...

Neurodegenerative diseases such as Alzheimer’s disease and related disorders, are characterized by progressive decline in cognitive function and neuronal ...

A team of scientists led by the University of Oxford have achieved a significant breakthrough in detecting modifications on protein structures. The method, published in Nature Nanotechnology, employs ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Respiratory infections, pink eye, or an upset stomach may seem like unrelated, mild inconveniences, but all of these ailments share one root cause: adenovirus infection. Many of us will encounter some ...

Tuberculosis is a serious health threat, and the efficacy of the BCG vaccine against tuberculosis diminishes in adulthood, making booster vaccines a realistic option. Mycobacterial DNA-binding protein ...

image: An engineered protein nanopore directed a water flux strong enough to capture, unfold and translocate proteins exceeding 1200 amino acids in length. Modulation of electrical current during ...

Whole blood derived from six adult donors who were inoculated with BCG in their childhood was cultured with MDP1 alone, MDP1 in combination with G9.1, or in combination with the negative form of ...