Hyperpathia, hyperalgesia, and allodynia are three manifestations of central sensitization, a condition in which a higher than necessary degree of activity is triggered in the central nervous system.
Some of the central molecular mechanisms that lead to hyperalgesia and allodynia after peripheral tissue injury involve the spinal dorsal horn transient receptor potential vanilloid 1 (TRPV1).
"Understanding the mechanisms underlying tolerance and hyperalgesia is essential to enhance morphine's utility in chronic pain management," said Lingyong Li, Ph.D., an associate professor at the ...