An arctic blast will send temperatures across the United States plummeting as bitterly cold air that originated in Siberia will arrive from Canada by week’s end, bringing with it dangerously cold wind chills for millions of Americans.

Snow and winds are likely to trigger flight cancellations and cause headaches for people traveling to DC for Inauguration Day.

Temperatures will plummet by up to 40 degrees this weekend as an arctic blast spreads across much of the U.S., including the Deep South.