The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...

Endoplasmic reticulum (ER) proteostasis is regulated by the adaptive unfolded protein response (UPR) pathway, which determines cell fate and maintains cell structure and function Stress (hypoxia, ...

Paul Victor, Dhamodharan Umapathy, Leema George, Udyama Juttada, Goutham V. Ganesh, Karan Naresh Amin, Vijay Viswanathan and Kunka Mohanram Ramkumar Increasing evidence in substantiating the roles of ...

Gene transfer of SERCA2a improves contractility and myocardial energetics in the setting of heart failure Overexpression of SERCA2a has antiproliferative and vasodilatory effects on the vasculature ...