DNA phosphorothioate modification is a distinctive epigenetic alteration in which a non‐bridging oxygen atom within the DNA sugar-phosphate backbone is replaced by ...

The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved. But DNA ...

Long non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins. Once considered mere transcriptional noise, lncRNAs are now known to play vital roles in ...

UCLA researchers analyzed a certain type of DNA marker across hundreds of mammal species and found associations with traits such as lifespan, weight and age. The study, published in August, examined ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Epigenetics is the study of how our cells alter their function by modifying gene expression in our genetic code or deoxyribonucleic acid (DNA). In our cells, DNA is constantly being used to generate ...

A UCLA-led study has provided an unprecedented look at how gene regulation evolves during human brain development, showing how the 3D structure of chromatin — DNA and proteins — plays a critical role.

CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

An important DNA modification is methylation, or the addition of a methyl group to the 5th carbon of cytosine. This forms 5-methylcytosine (5mC), typically associated with repression of gene ...

Genome editing is a powerful biotechnology tool that allows scientists to make precise changes to an organism's DNA. It involves the use of specialized enzymes, known as engineered nucleases or ...

A new study has created a map of DNA modification in two regions of the brain critical to learning, memory and emotional regulation. The map offers a benchmark for ensuring stem cell-based models ...